Injectable bioactive glass in the restoration of oral bone defect.

OBJECTIVE To explore the application value of injectable bioactive glass in the restoration of the oral bone defect. PATIENTS AND METHODS This study included 58 consecutive patients with oral bone defect > 1 mm, these patients were randomly assigned to a control group (n=26, Hydroxyapatite bioceramics) and an observation group (n=32, Injectable bioactive glass). The purpose of this study was to assess the comparison of the healing of oral bone defect. RESULTS X-ray examination was performed at 6-month and 12-month following treatment. The bone healing in the observation group was significantly better than the control group (p <0.05), the incidences of local rejection reactions were not significantly different (p >0.05). Cone-beam Computed Tomography (CBCT) was performed at 6-month and 12-month following treatment. The mean bone thickness in the observation group was significantly lower than the control group, p <0.05. Both the levels of bone morphogenetic protein 2 (BMP-2) and transforming growth factor β (TGF-β) in the observation group were significantly higher than the control group, p <0.05. CONCLUSIONS The effect of injectable bioactive glass in the restoration of the oral bone defect was better than hydroxyapatite bioceramics. Thus, injectable bioactive glass has great application value.